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Article

Allelic polymorphism in the T cell receptor and its impact on immune responses.

The Journal of experimental medicine - 5 Jul 2010

Gras Stephanie, Chen Zhenjun, Miles John J, Liu Yu Chih, Bell Melissa J, Sullivan Lucy C, Kjer-Nielsen Lars, Brennan Rebekah M, Burrows Jacqueline M, Neller Michelle A, Khanna Rajiv, Purcell Anthony W, Brooks Andrew G, McCluskey James, Rossjohn Jamie, Burrows Scott R

Abstract excerpt

In comparison to human leukocyte antigen (HLA) polymorphism, the impact of allelic sequence variation within T cell receptor (TCR) loci is much less understood. Particular TCR loci have been associated with autoimmunity, but the molecular basis for this phenomenon is undefined. We examined the T cell response to an HLA-B*3501-restricted epitope (HPVGEADYFEY) from Epstein-Barr virus (EBV), which is frequently...

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Identifiers

PMID: 20566715
DOI: 10.1084/jem.20100603
PMCID: PMC2901058

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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