Article
Spectrum of germline mutations in smokers and non-smokers in Brazilian non-small-cell lung cancer (NSCLC) patients.
Carcinogenesis - 26 Oct 2017
Couto Patrícia P, Bastos-Rodrigues Luciana, Schayek Hagit, Melo Flavia M, Lisboa Raony G C, Miranda Debora M, Vilhena Alyne, Bale Allen E, Friedman Eitan, De Marco Luiz
Abstract excerpt
Lung cancer (LC) is a leading cause of cancer-related mortality. Although smoking is the major risk factor, ~15% of all cases occur in never-smokers, suggesting that genetic factors play a role in LC predisposition. Indeed, germline mutations in the TP53 gene predispose to multiple cancer types, including LC. To date, few studies compared the somatic and germline mutational profiles of LC cases by smoking status,...
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