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Article

The role of germline mutations in non-small cell lung cancer: A systematic review of emerging genetic drivers and clinical implications.

Critical reviews in oncology/hematology - 1 Jul 2026

Gentile G, Gelibter A, De Marchis L, Pappalardo L, Capasso C, Giusti R, Botticelli A, Mazzuca F, Santini D, Siringo M

Abstract excerpt

BACKGROUND: Lung cancer is the second most common malignancy and the leading cause of cancer-related mortality worldwide. While tobacco exposure remains the main risk factor, 15-20% of cases occur in never-smokers, suggesting a role for genetic predisposition. Although infrequent compared to somatic alterations, germline alterations may contribute to non-small cell lung cancer (NSCLC) susceptibility, with...

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Identifiers

PMID: 41933854
DOI: 10.1016/j.critrevonc.2026.105307

Genes

ATM
BRCA1
CHEK2
EGFR
PALB2
TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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