Molecular profile of driver genes in lung adenocarcinomas of Brazilian patients who have never smoked: implications for targeted therapies.

doi:10.1093/oncolo/oyae129

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Article

Molecular profile of driver genes in lung adenocarcinomas of Brazilian patients who have never smoked: implications for targeted therapies.

The oncologist - 3 Oct 2024

Cavagna Rodrigo de Oliveira, Escremim de Paula Flávia, Berardinelli Gustavo Noriz, Bonatelli Murilo, Santana Iara, Albino da Silva Eduardo Caetano, Teixeira Gustavo Ramos, Zaniolo Beatriz Garbe, Mourão Dias Josiane, Ferreira da Silva Flávio Augusto, Baston Silva Carlos Eduardo, Guimarães Marcela Gondim Borges, Barone Camila Pinto, Jacinto Alexandre Arthur, Noleto da Nóbrega Oliveira Rachid Eduardo, Miziara José Elias, De Marchi Pedro, Molina-Vila Miguel A, Leal Letícia Ferro, Reis Rui Manuel

Abstract excerpt

INTRODUCTION: Lung cancer in never-smoker (LCINS) patients accounts for 20% of lung cancer cases, and its biology remains poorly understood, particularly in genetically admixed populations. We elucidated the molecular profile of driver genes in Brazilian LCINS. METHODS: The mutational and gene fu...

Topics

Humans
Adenocarcinoma of Lung
Male
Female
Brazil
Middle Aged
Lung Neoplasms
Aged
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Adult

Molecular Targeted Therapy

Aged, 80 and over

Biomarkers, Tumor

Source

Open in PubMed Open full text

Identifiers

PMID: 38944844
DOI: 10.1093/oncolo/oyae129
PMCID: PMC11449088

Genes

TP53
ALK
PIK3CA
BRAF
EGFR
ERBB2
KRAS
MET
NTRK1
PDGFRA
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-38944844-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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