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The Role of Germline Mutations in Thoracic Malignancies: Between Myth and Reality.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Sept 2023

Farinea Giovanni, Crespi Veronica, Listì Angela, Righi Luisella, Bironzo Paolo, Merlini Alessandra, Malapelle Umberto, Novello Silvia, Scagliotti Giorgio Vittorio, Passiglia Francesco

Abstract excerpt

Considering the established contribution of environmental factors to the development of thoracic malignancies, the inherited susceptibility of these tumors has rarely been explored. However, the recent introduction of next-generation sequencing-based tumor molecular profiling in the real-word setting enabled us to deeply characterize the genomic background of patients with lung cancer with or without...

Topics

Humans
Germ-Line Mutation
Lung Neoplasms
Mesothelioma, Malignant
Mesothelioma
Carcinoma, Non-Small-Cell Lung
Genetic Predisposition to Disease

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 37331604
DOI: 10.1016/j.jtho.2023.05.028

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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