Disruptive and Truncating TP53 Mutations Are Associated with African-Ancestry and Worse Prognosis in Brazilian Patients with Lung Adenocarcinoma.

doi:10.1159/000530587

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Disruptive and Truncating TP53 Mutations Are Associated with African-Ancestry and Worse Prognosis in Brazilian Patients with Lung Adenocarcinoma.

Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 2023

Cavagna Rodrigo de Oliveira, Pinto Icaro Alves, Escremim de Paula Flávia, Berardinelli Gustavo Noriz, Sant'Anna Débora, Santana Iara, da Silva Vinicius Duval, Da Silva Eduardo Caetano Albino, Miziara José Elias, Mourão Dias Josiane, Antoniazzi Augusto, Jacinto Alexandre, De Marchi Pedro, Molina-Vila Miguel Angel, Ferro Leal Leticia, Reis Rui Manuel

Abstract excerpt

INTRODUCTION: TP53 is the most frequently mutated gene in lung tumors, but its prognostic role in admixed populations, such as Brazilians, remains unclear. In this study, we aimed to evaluate the frequency and clinicopathological impact of TP53 mutations in non-small cell lung cancer (NSCLC) patients in Brazil. METHODS: We analyzed 446 NSCLC patients from Barretos Cancer Hospital. TP53 mutational status was...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Black People

Share to Brazil

Share to Carcinoma, Non-Small-Cell Lung

Share to Lung Neoplasms

Share to Prevalence

Share to Prognosis

Share to Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 37031678
DOI: 10.1159/000530587

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disruptive and Truncating TP53 Mutations Are Associated with African-Ancestry and Worse Prognosis in Brazilian Patients with Lung Adenocarcinoma.PMID 37031678Read ↗

Spectrum of germline mutations in smokers and non-smokers in Brazilian non-small-cell lung cancer (NSCLC) patients.Semantic proximity Read ↗

Mutational profile of Brazilian lung adenocarcinoma unveils association of EGFR mutations with high Asian ancestry and independent prognostic role of KRAS mutationsSemantic proximity Read ↗

Molecular profile of driver genes in lung adenocarcinomas of Brazilian patients who have never smoked: implications for targeted therapies.Semantic proximity Read ↗

Genetic Ancestry and Somatic Mutations in Lung Adenocarcinoma: Insights from Real-World Clinico-Genomic DataSemantic proximity Read ↗

The Clinical and Molecular Profile of Lung Cancer Patients Harboring the TP53 R337H Germline Variant in a Brazilian Cancer Center: The Possible Mechanism of Carcinogenesis.Semantic proximity Read ↗

Comprehensive genomic profiling of Brazilian non-small cell lung cancer patients (GBOT 0118/LACOG0418).Semantic proximity Read ↗

The role of germline mutations in non-small cell lung cancer: A systematic review of emerging genetic drivers and clinical implications.Semantic proximity Read ↗

Ancestry-, Sex-, and Age-Based Differences of Gene Alterations in NSCLC: From the Real-World Data of Cancer Genomic Profiling Tests.Semantic proximity Read ↗

Lung adenocarcinomas with isolated TP53 mutation: A comprehensive clinical, cytopathologic and molecular characterization.Semantic proximity Read ↗

TP53 Mutation Mapping in Advanced Non-Small Cell Lung Cancer: A Real-World Retrospective Cohort Study.Semantic proximity Read ↗

TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer PatientsSemantic proximity Read ↗

Concomitant TP53 mutation in early-stage resected EGFR-mutated non-small cell lung cancer: a narrative approach in a genetically admixed Brazilian cohort.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.