Article
The Clinical and Molecular Profile of Lung Cancer Patients Harboring the TP53 R337H Germline Variant in a Brazilian Cancer Center: The Possible Mechanism of Carcinogenesis.
International journal of molecular sciences - 10 Oct 2023
Lopes Carlos D H, Antonacio Fernanda F, Moraes Priscila M G, Asprino Paula F, Galante Pedro A F, Jardim Denis L, de Macedo Mariana P, Sandoval Renata L, Katz Artur, de Castro Gilberto, Achatz Maria Isabel
Abstract excerpt
In southern and southeastern Brazil, the TP53 founder variant c.1010G>A (R337H) has been previously documented with a prevalence of 0.3% within the general population and linked to a heightened incidence of lung adenocarcinomas (LUADs). In the present investigation, we cover clinical and molecular characterizations of lung cancer patients from the Brazilian Li-Fraumeni Syndrome Study (BLISS) database. Among the...
Topics
- Female
- Humans
- Aged
- Li-Fraumeni Syndrome
- Brazil
- Tumor Suppressor Protein p53
- Lung Neoplasms
- Genetic Predisposition to Disease
- Germ-Line Mutation