Article
TNF-α promoter variant (G-308A) is associated with susceptibility to P. falciparum infection and severe malaria: a meta-analysis and trial sequential analysis.
Nucleosides, nucleotides & nucleic acids - 1 Jan 2023
Sarangi Surjyapratap, Nahak Suraj Kuamr, Padhi Sunali, Nayak Nisha, Pradhan Bidyutprabha, Pati Abhijit, Panigrahi Jogeswar, Panda Aditya K
Abstract excerpt
Tumor necrosis factor-alpha (TNF-α) plays an essential role in Plasmodium falciparum infection, with lower levels associated with susceptibility to infection and higher levels linked with organ failure in severe malaria. Genetic polymorphisms in the promoter region of the TNF-α gene (G-308A and G-238A) affect plasma TNF-α levels. Numerous case-control studies have been conducted to determine the possible...
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