Article
Widespread epistasis regulates glucose homeostasis and gene expression.
PLoS genetics - 1 Sept 2017
Chen Anlu, Liu Yang, Williams Scott M, Morris Nathan, Buchner David A
Abstract excerpt
The relative contributions of additive versus non-additive interactions in the regulation of complex traits remains controversial. This may be in part because large-scale epistasis has traditionally been difficult to detect in complex, multi-cellular organisms. We hypothesized that it would be easier to detect interactions using mouse chromosome substitution strains that simultaneously incorporate allelic...
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