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Article

Weak Epistasis Generally Stabilizes Phenotypes in a Mouse Intercross.

PLoS genetics - 1 Feb 2016

Tyler Anna L, Donahue Leah Rae, Churchill Gary A, Carter Gregory W

Abstract excerpt

The extent and strength of epistasis is commonly unresolved in genetic studies, and observed epistasis is often difficult to interpret in terms of biological consequences or overall genetic architecture. We investigated the prevalence and consequences of epistasis by analyzing four body composition phenotypes--body weight, body fat percentage, femoral density, and femoral circumference--in a large F2 intercross...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26828925
DOI: 10.1371/journal.pgen.1005805
PMCID: PMC4734753

Genes

IGF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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