Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice.

doi:10.1186/1471-2156-13-38

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Article

Genetic divergence and the genetic architecture of complex traits in chromosome substitution strains of mice.

BMC genetics - 18 May 2012

Spiezio Sabrina H, Takada Toyoyuki, Shiroishi Toshihiko, Nadeau Joseph H

Abstract excerpt

BACKGROUND: The genetic architecture of complex traits strongly influences the consequences of inherited mutations, genetic engineering, environmental and genetic perturbations, and natural and artificial selection. But because most studies are under-powered, the picture of complex traits is often incomplete. Chromosome substitution strains (CSSs) are a unique paradigm for these genome surveys because they enable...

Topics

Animals
Chromosomes, Mammalian
Crosses, Genetic
Inheritance Patterns
Mice
Mice, Inbred C57BL
Phenotype
Quantitative Trait Loci

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Identifiers

PMID: 22606935
DOI: 10.1186/1471-2156-13-38
PMCID: PMC3406986

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