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Article

Epistasis and quantitative traits: using model organisms to study gene-gene interactions.

Nature reviews. Genetics - 1 Jan 2014

Mackay Trudy F C

Abstract excerpt

The role of epistasis in the genetic architecture of quantitative traits is controversial, despite the biological plausibility that nonlinear molecular interactions underpin the genotype-phenotype map. This controversy arises because most genetic variation for quantitative traits is additive. However, additive variance is consistent with pervasive epistasis. In this Review, I discuss experimental designs to...

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Identifiers

PMID: 24296533
DOI: 10.1038/nrg3627
PMCID: PMC3918431

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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