Article
Mouse inter-subspecific consomic strains for genetic dissection of quantitative complex traits.
Genome research - 1 Mar 2008
Takada Toyoyuki, Mita Akihiko, Maeno Akiteru, Sakai Takahiro, Shitara Hiroshi, Kikkawa Yoshiaki, Moriwaki Kazuo, Yonekawa Hiromichi, Shiroishi Toshihiko
Abstract excerpt
Consomic strains, also known as chromosome substitution strains, are powerful tools for assigning polygenes that control quantitative complex traits to specific chromosomes. Here, we report generation of a full set of mouse consomic strains, in which each chromosome of the common laboratory strain C57BL/6J (B6) is replaced by its counterpart from the inbred strain MSM/Ms, which is derived from Japanese wild...
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