IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits.

doi:10.1038/s41598-017-12393-5

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Article

IRS1 DNA promoter methylation and expression in human adipose tissue are related to fat distribution and metabolic traits.

Scientific reports - 28 Sept 2017

Rohde Kerstin, Klös Matthias, Hopp Lydia, Liu Xuanshi, Keller Maria, Stumvoll Michael, Dietrich Arne, Schön Michael R, Gärtner Daniel, Lohmann Tobias, Dreßler Miriam, Kovacs Peter, Binder Hans, Blüher Matthias, Böttcher Yvonne

Abstract excerpt

The SNP variant rs2943650 near IRS1 gene locus was previously associated with decreased body fat and IRS1 gene expression as well as an adverse metabolic profile in humans. Here, we hypothesize that these effects may be mediated by an interplay with epigenetic alterations. We measured IRS1 promoter DNA methylation and mRNA expression in paired human subcutaneous and omental visceral adipose tissue samples (SAT...

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Identifiers

PMID: 28959056
DOI: 10.1038/s41598-017-12393-5
PMCID: PMC5620072

Genes

IRS1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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