Article
Adipose tissue depot specific promoter methylation of TMEM18.
Journal of molecular medicine (Berlin, Germany) - 1 Aug 2014
Rohde Kerstin, Keller Maria, Klös Matthias, Schleinitz Dorit, Dietrich Arne, Schön Michael R, Gärtner Daniel, Lohmann Tobias, Dreßler Miriam, Stumvoll Michael, Kovacs Peter, Blüher Matthias, Böttcher Yvonne
Abstract excerpt
UNLABELLED: Epigenetic processes such as dynamic promoter methylation may play a role in obesity, fat distribution and its accompanied metabolic alterations. TMEM18 is a candidate gene for body mass index (BMI) comprising the second largest effect size among all loci identified so far via GWAS. We hypothesized that differential TMEM18 gene expression in visceral (VAT) and subcutaneous adipose tissue (SAT) may be...
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