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Article

Detailed structure of mouse interferon α2 and its interaction with Sortilin.

Journal of biochemistry - 11 Oct 2021

Watanabe Honoka, Yabe-Wada Toshiki, Onai Nobuyuki, Unno Masaki

Abstract excerpt

Interferon α (IFNα) is a type I interferon, an essential cytokine employed by the immune system to fight viruses. Although a number of the structures of type I interferons have been reported, most of the known structures of IFNα are in complex with its receptors. There are only two examples of structures of free IFNα: one is a dimeric X-ray structure without side-chain information; and another is an NMR structure...

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Share to Adaptor Proteins, Vesicular Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33769476
DOI: 10.1093/jb/mvab038

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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