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Article

Differential receptor subunit affinities of type I interferons govern differential signal activation.

Journal of molecular biology - 16 Feb 2007

Jaks Eva, Gavutis Martynas, Uzé Gilles, Martal Jacques, Piehler Jacob

Abstract excerpt

Type I interferons (IFNs) elicit antiviral, antiproliferative and immunmodulatory responses by binding to a shared cell surface receptor comprising the transmembrane proteins ifnar1 and ifnar2. Activation of differential response patterns by IFNs has been observed, suggesting that members of the family play different roles in innate immunity. The molecular basis for differential signaling has not been identified...

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Identifiers

PMID: 17174979
DOI: 10.1016/j.jmb.2006.11.053

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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