Article
Identification of Interferon Receptor IFNAR2 As a Novel HCV Entry Factor by Using Chemical Probes.
ACS chemical biology - 15 May 2020
Qing Jie, Wu Ming, Luo Rui, Chen Jizheng, Cao Lin, Zeng Debin, Shang Luqing, Nong Junxiu, Wu Qinkai, Ding Bi-Sen, Chen Xinwen, Rao Zihe, Liu Lei, Lou Zhiyong
Abstract excerpt
Upon sensing pathogen-associated patterns and secreting interferons (IFNs) into the environment, host cells perceive extracellular type I IFNs by the IFNα/β receptors IFNAR1 and IFNAR2 to stimulate downstream innate immune signaling cascades. Through the use of chemical probes, we demonstrated that IFNAR2 facilitates hepatitis C virus (HCV) entry. Silencing of IFNAR2 significantly attenuated HCV proliferation....
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