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Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.

Journal of immunology (Baltimore, Md. : 1950) - 15 Nov 2015

Fraser Heather I, Howlett Sarah, Clark Jan, Rainbow Daniel B, Stanford Stephanie M, Wu Dennis J, Hsieh Yi-Wen, Maine Christian J, Christensen Mikkel, Kuchroo Vijay, Sherman Linda A, Podolin Patricia L, Todd John A, Steward Charles A, Peterson Laurence B, Bottini Nunzio, Wicker Linda S

Abstract excerpt

By congenic strain mapping using autoimmune NOD.C57BL/6J congenic mice, we demonstrated previously that the type 1 diabetes (T1D) protection associated with the insulin-dependent diabetes (Idd)10 locus on chromosome 3, originally identified by linkage analysis, was in fact due to three closely linked Idd loci: Idd10, Idd18.1, and Idd18.3. In this study, we define two additional Idd loci--Idd18.2 and...

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B-Lymphocytes
CD2 Antigens
Chromosomes, Mammalian
Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred NOD

Protein Tyrosine Phosphatase, Non-Receptor Type 22

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Identifiers

PMID: 26438525
DOI: 10.4049/jimmunol.1402654
PMCID: PMC4635565

Genes

PTPN22

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Ptpn22 and Cd2 Variations Are Associated with Altered Protein Expression and Susceptibility to Type 1 Diabetes in Nonobese Diabetic Mice.PMID 26438525Read ↗

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