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Article

Oncogenic RAS-induced CK1α drives nuclear FOXO proteolysis.

Oncogene - 18 Jan 2018

Zhang F, Virshup D M, Cheong J K

Abstract excerpt

Evasion of forkhead box O (FOXO) family of longevity-related transcription factors-mediated growth suppression is necessary to promote cancer development. Since somatic alterations or mutations and transcriptional dysregulation of the FOXO genes are infrequent in human cancers, it remains unclear how these tumour suppressors are eliminated from cancer cells. The protein stability of FOXO3A is regulated by Casein...

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Source

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Identifiers

PMID: 28945225
DOI: 10.1038/onc.2017.334
PMCID: PMC5799771

Genes

FOXO4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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