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Article

The discrete roles of individual FOXO transcription factor family members in B-cell malignancies

18 May 2023

Abstract excerpt

Forkhead box (FOX) class O (FOXO) proteins are a dynamic family of transcription factors composed of four family members: FOXO1, FOXO3, FOXO4 and FOXO6. As context-dependent transcriptional activators and repressors, the FOXO family regulates diverse cellular processes including cell cycle arrest, apoptosis, metabolism, longevity and cell fate determination. A central pathway responsible for negative regulation...

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PMID: 37275916
DOI: 10.3389/fimmu.2023.1179101

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