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Article

Biochemical analysis of MST1 kinase: elucidation of a C-terminal regulatory region.

Biochemistry - 24 Jun 2008

Anand Ruchi, Kim Ah-Young, Brent Michael, Marmorstein Ronen

Abstract excerpt

The MST1 kinase phosphorylates FoxO transcription factors in the cytosol and histone H2B in the nucleus to promote cellular apoptosis. In addition to a N-terminal kinase domain, MST1 contains C-terminal regulatory and dimerization regions that are cleaved upon nuclear transport. In this report, we investigate the role of the MST1 regulatory region and dimerization domain in MST1 activity toward FoxO and histone...

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Share to Enzyme Activation
Share to Forkhead Box Protein O1
Share to Forkhead Transcription Factors

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Intracellular Signaling Peptides and Proteins

Share to Protein Multimerization

Share to Regulatory Sequences, Nucleic Acid

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Source

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Identifiers

PMID: 18510339
DOI: 10.1021/bi800309m
PMCID: PMC2844906

Genes

MST1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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