Article
RhoB facilitates c-Myc turnover by supporting efficient nuclear accumulation of GSK-3.
Oncogene - 2 Mar 2006
Huang M, Kamasani U, Prendergast G C
Abstract excerpt
The small GTPase RhoB suppresses cancer in part by limiting cell proliferation. However, the mechanisms it uses to achieve this are poorly understood. Recent studies link RhoB to trafficking of Akt, which through its regulation of glycogen synthase kinase-3 (GSK-3) has an important role in controlling the stability of the c-Myc oncoprotein. c-Myc stabilization may be a root feature of human tumorigenesis as it...
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