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Forkhead box-O transcription factor: critical conductors of cancer's fate

5 Sept 2008

Abstract excerpt

Cells have evolved elaborated mechanisms to coordinate the cellular answer of either survival or apoptosis. Recent concepts of human carcinogenesis have suggested disturbances in these cellular relays as a potential link to cellular dedifferentiation and uncontrolled proliferation. Forkhead box-O transcription factors (FOXOs) play an important role in tumour suppression by regulating the expression of genes...

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PMID: 18775975
DOI: 10.1677/erc-08-0153

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