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Article

Mitotic arrest by tumor suppressor RASSF1A is regulated via CHK1 phosphorylation.

Molecular cancer research : MCR - 1 Jan 2014

Jiang Lingyan, Rong Rong, Sheikh M Saeed, Huang Ying

Abstract excerpt

UNLABELLED: The tumor suppressor RAS-association domain family 1 isoform A (RASSF1A) is known to play an important role in cell-cycle regulation. However, the molecular details about RASSF1A protein regulation are unclear. In this report, checkpoint kinase 1 (CHK1) is identified as a novel RASSF1A kinase that phosphorylates RASSF1A in vitro and under cellular conditions. Using tandem mass spectrometry and...

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Identifiers

PMID: 24197116
DOI: 10.1158/1541-7786.MCR-13-0482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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