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<scp>AKT</scp> signalling is required for ribosomal <scp>RNA</scp> synthesis and progression of <scp>E</scp>μ‐<i>Myc </i><scp>B</scp>‐cell lymphoma <i>in vivo</i>

19 Jan 2013

Abstract excerpt

The dysregulation of PI3K/AKT/mTORC1 signalling and/or hyperactivation of MYC are observed in a high proportion of human cancers, and together they form a 'super signalling' network mediating malignancy. A fundamental downstream action of this signalling network is up-regulation of ribosome biogenesis and subsequent alterations in the patterns of translation and increased protein synthesis, which are thought to...

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PMID: 23331925
DOI: 10.1111/febs.12135

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<scp>AKT</scp> signalling is required for ribosomal <scp>RNA</scp> synthesis and progression of <scp>E</scp>μ‐<i>Myc </i><scp>B</scp>‐cell lymphoma <i>in vivo</i>PMID 23331925Read ↗

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