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Nuclear IRS‐1 and cancer

22 Dec 2011

Abstract excerpt

The family of insulin receptor substrates (IRS) consists of four proteins (IRS-1-IRS-4), which were initially characterized as typical cytosolic adaptor proteins involved in insulin receptor (IR) and insulin-like growth factor I receptor (IGF-IR) signaling. The first cloned and characterized member of the IRS family, IRS-1, has a predicted molecular weight of 132 kDa, however, as a result of its extensive serine...

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PMID: 22454254
DOI: 10.1002/jcp.24019

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