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Article

Dynamic regulation of the Ras pathway via proteolysis of the NF1 tumor suppressor.

Genes & development - 15 Feb 2003

Cichowski Karen, Santiago Sabrina, Jardim Melanie, Johnson Bryan W, Jacks Tyler

Abstract excerpt

Mutations in the NF1 tumor suppressor underlie the familial tumor predisposition syndrome neurofibromatosis type I. Although its encoded protein, neurofibromin, functions as a Ras-GTPase activating protein (GAP), nothing is known about how it is normally regulated or its precise role in controlling Ras signaling pathways. We show here that neurofibromin is dynamically regulated by the ubiquitin-proteasome...

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Identifiers

PMID: 12600938
DOI: 10.1101/gad.1054703
PMCID: PMC195996

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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