Article

Nuclear translocation of p85β promotes tumorigenesis of PIK3CA helical domain mutant cancer

2021-05-05

Abstract excerpt

<title>Abstract</title> <p>PI3Ks consist of p110 catalytic subunits and p85 regulatory subunits. PIK3CA, encoding p110, is frequently mutated in human cancers. Most PIK3CA mutations are clustered in the helical domain or the kinase domain. Here, we report that p85 disassociates from p110α helical domain mutant protein and translocates into the nucleus through a nuclear localization sequence (NLS). Nuclear p85β...

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Identifiers and source

Literature Corpus work: 63557142-84a0-533e-8174-66566f0da911
DOI: 10.21203/rs.3.rs-462020/v1

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