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Article

Movement decline across lifespan of Caenorhabditis elegans mutants in the insulin/insulin-like signaling pathway.

Aging cell - 1 Feb 2018

Newell Stamper Breanne L, Cypser James R, Kechris Katerina, Kitzenberg David Alan, Tedesco Patricia M, Johnson Thomas E

Abstract excerpt

Research in aging biology has identified several pathways that are molecularly conserved across species that extend lifespan when mutated. The insulin/insulin-like signaling (IIS) pathway is one of the most widely studied of these. It has been assumed that extending lifespan also extends healthspan (the period of life with minimal functional loss). However, data supporting this assumption conflict and recent...

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Identifiers

PMID: 29214707
DOI: 10.1111/acel.12704
PMCID: PMC5770877

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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