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DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells.

Cell reports - 19 Sept 2017

Sanosaka Tsukasa, Imamura Takuya, Hamazaki Nobuhiko, Chai MuhChyi, Igarashi Katsuhide, Ideta-Otsuka Maky, Miura Fumihito, Ito Takashi, Fujii Nobuyuki, Ikeo Kazuho, Nakashima Kinichi

Abstract excerpt

Regulation of the epigenome during in vivo specification of brain stem cells is still poorly understood. Here, we report DNA methylome analyses of directly sampled cortical neural stem and progenitor cells (NS/PCs) at different development stages, as well as those of terminally differentiated cortical neurons, astrocytes, and oligodendrocytes. We found that sequential specification of cortical NS/PCs is regulated...

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PMID: 28930691
DOI: 10.1016/j.celrep.2017.08.086

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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