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Article

ABCG2 regulatory single-nucleotide polymorphisms alter in vivo enhancer activity and expression.

Pharmacogenetics and genomics - 1 Dec 2017

Eclov Rachel J, Kim Mee J, Chhibber Aparna, Smith Robin P, Ahituv Nadav, Kroetz Deanna L

Abstract excerpt

OBJECTIVES: The expression and activity of the breast cancer resistance protein (ABCG2) contributes toward the pharmacokinetics of endogenous and xenobiotic substrates. The effect of genetic variation on the activity of cis-regulatory elements and nuclear response elements in the ABCG2 locus and their contribution toward ABCG2 expression have not been investigated systematically. In this study, the effect of...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28930109
DOI: 10.1097/FPC.0000000000000312
PMCID: PMC5678922

Genes

ABCG2

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