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Article

Pharmacogenetics of estrogen metabolism and transport in relation to cancer.

Current drug metabolism - 1 Dec 2003

Lakhani Nehal J, Venitz Jürgen, Figg William D, Sparreboom Alex

Abstract excerpt

Exposure to estrogens has been long associated with the genesis of human malignancies, including breast, ovarian, and endometrial cancer. A variety of phase I and II enzymes are involved in the metabolic activation and de-activation of estrogens, including cytochrome p450 isoforms, estrone sulfatase, sulfotransferases, catechol-o-methyltransferase, and uridine-5'-diphosphate glucuronosyltransferase. In addition,...

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Identifiers

PMID: 14683478
DOI: 10.2174/1389200033489244

Genes

ABCG2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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