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Article

Rare Variants in the ABCG2 Promoter Modulate In Vivo Activity.

Drug metabolism and disposition: the biological fate of chemicals - 1 May 2018

Eclov Rachel J, Kim Mee J, Smith Robin, Ahituv Nadav, Kroetz Deanna L

Abstract excerpt

ABCG2 encodes the breast cancer resistance protein (BCRP), an efflux membrane transporter important in the detoxification of xenobiotics. In the present study, the basal activity of the ABCG2 promoter in liver, kidney, intestine, and breast cell lines was examined using luciferase reporter assays. The promoter activities of reference and variant ABCG2 sequences were compared in human hepatocellular carcinoma cell...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 29467213
DOI: 10.1124/dmd.117.079541
PMCID: PMC5896364

Genes

ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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