Article
The phenobarbital response enhancer module in the human bilirubin UDP-glucuronosyltransferase UGT1A1 gene and regulation by the nuclear receptor CAR.
Hepatology (Baltimore, Md.) - 1 May 2001
Sugatani J, Kojima H, Ueda A, Kakizaki S, Yoshinari K, Gong Q H, Owens I S, Negishi M, Sueyoshi T
Abstract excerpt
The UDP-glucuronosyltransferase, UGT1A1, is the critical enzyme responsible for detoxification of the potentially neurotoxic bilirubin by conjugating it with glucuronic acid. For decades, phenobarbital (PB) treatment for hyperbilirubinemia has been known to increase expression of the UGT1A1 gene in liver. We have now delineated the PB response activity to a 290-bp distal enhancer sequence (-3483/-3194) of the...
Topics
- Base Sequence
- Cells, Cultured
- Constitutive Androstane Receptor
- DNA
- Enhancer Elements, Genetic
- Gene Deletion
- Gene Expression Regulation
- Glucuronosyltransferase
- Humans
- Molecular Sequence Data