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Article

A pharmacogenomics study of the human estrogen glucuronosyltransferase UGT1A3.

Pharmacogenetics and genomics - 1 Jul 2007

Caillier Bertrand, Lépine Johanie, Tojcic Jelena, Ménard Vincent, Perusse Louis, Bélanger Alain, Barbier Olivier, Guillemette Chantal

Abstract excerpt

UGT1A3 is one of the most efficient at conjugating estrone, a precursor for biosynthesis of estradiol in peripheral tissues. We established the genetic mechanisms that might contribute to individual variation in UGT1A3 expression and activity. UGT1A3 first exon and 5'-flanking regions were sequenced in 249 Caucasians. We identified 17 polymorphisms, among them seven regulatory and 10 exonic polymorphisms with six...

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Identifiers

PMID: 17558304
DOI: 10.1097/FPC.0b013e32806d87a4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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