Article
Discovery of regulatory elements in human ATP-binding cassette transporters through expression quantitative trait mapping.
The pharmacogenomics journal - 1 Jun 2012
Matsson P, Yee S W, Markova S, Morrissey K, Jenkins G, Xuan J, Jorgenson E, Kroetz D L, Giacomini K M
Abstract excerpt
ATP-binding cassette (ABC) membrane transporters determine the disposition of many drugs, metabolites and endogenous compounds. Coding region variation in ABC transporters is the cause of many genetic disorders, but much less is known about the genetic basis and functional outcome of ABC transporter expression level variation. We used genotype and mRNA transcript level data from human lymphoblastoid cell lines to...
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