SNP discovery, expression and cis-regulatory variation in the UGT2B genes.

doi:10.1038/tpj.2011.2

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Article

SNP discovery, expression and cis-regulatory variation in the UGT2B genes.

The pharmacogenomics journal - 1 Aug 2012

Sun C, Southard C, Huo D, Hernandez R D, Witonsky D B, Olopade O I, Di Rienzo A

Abstract excerpt

UGT2B enzymes metabolize multiple endogenous and exogenous molecules, including steroid hormones and clinical drugs. However, little is known about the inter-individual variation in gene expression and its determinants. We re-sequenced candidate regulatory regions and the partial coding regions (41.1 kb) of UGT2B genes and identified 332 genetic variants. We measured gene expression in normal breast and liver...

Topics

Breast
Female
Gene Expression Profiling
Glucuronosyltransferase
Humans
Liver
Male
Polymorphism, Single Nucleotide
RNA, Messenger
Regulatory Sequences, Nucleic Acid

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Identifiers

PMID: 21358749
DOI: 10.1038/tpj.2011.2
PMCID: PMC4643740

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