Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SNP discovery, expression and cis-regulatory variation in the UGT2B genes.

The pharmacogenomics journal - 1 Aug 2012

Sun C, Southard C, Huo D, Hernandez R D, Witonsky D B, Olopade O I, Di Rienzo A

Abstract excerpt

UGT2B enzymes metabolize multiple endogenous and exogenous molecules, including steroid hormones and clinical drugs. However, little is known about the inter-individual variation in gene expression and its determinants. We re-sequenced candidate regulatory regions and the partial coding regions (41.1 kb) of UGT2B genes and identified 332 genetic variants. We measured gene expression in normal breast and liver...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast
Share to Gene Expression Profiling
Share to Glucuronosyltransferase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Polymorphism, Single Nucleotide

Share to Regulatory Sequences, Nucleic Acid

Share to RNA, Messenger

Source

Open in PubMed Open full text

Identifiers

PMID: 21358749
DOI: 10.1038/tpj.2011.2
PMCID: PMC4643740

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SNP discovery, expression and cis-regulatory variation in the UGT2B genes.PMID 21358749Read ↗

Genetic factors affecting gene transcription and catalytic activity of UDP-glucuronosyltransferases in human liver.Semantic proximity Read ↗

Allelic imbalance (AI) identifies novel tissue-specific cis-regulatory variation for human UGT2B15.Semantic proximity Read ↗

UGT pharmacogenomics: implications for cancer risk and cancer therapeutics.Semantic proximity Read ↗

Differential allelic expression of c.1568C > A at UGT2B15 is due to variation in a novel cis-regulatory element in the 3'UTR.Semantic proximity Read ↗

UGT genomic diversity: beyond gene duplication.Semantic proximity Read ↗

UGT pharmacogenomicsSemantic proximity Read ↗

A signature of balancing selection in the region upstream to the human UGT2B4 gene and implications for breast cancer risk.Semantic proximity Read ↗

Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y).Semantic proximity Read ↗

Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population.Semantic proximity Read ↗

Hepatic Abundance and Activity of Androgen- and Drug-Metabolizing Enzyme UGT2B17 Are Associated with Genotype, Age, and Sex.Semantic proximity Read ↗

Systematic genetic and genomic analysis of cytochrome P450 enzyme activities in human liver.Semantic proximity Read ↗

Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.