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Article

Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer.

Scientific reports - 15 Sept 2017

Thomsen Mathilde Borg Houlberg, Nordentoft Iver, Lamy Philippe, Vang Søren, Reinert Line, Mapendano Christophe Kamungu, Høyer Søren, Ørntoft Torben F, Jensen Jørgen Bjerggaard, Dyrskjøt Lars

Abstract excerpt

Genetic alterations identified in adjacent normal appearing tissue in bladder cancer patients are indicative of a field disease. Here we assessed normal urothelium transformation and intra-tumour heterogeneity (ITH) in four patients with bladder cancer. Exome sequencing identified private acquired mutations in a lymph node metastasis and local recurrences. Deep re-sequencing revealed presence of at least three...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28916750
DOI: 10.1038/s41598-017-11291-0
PMCID: PMC5600970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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