Article
Integrated Genomic and Single-Cell Analysis Reveals Heterogeneity, Prognosis, and Treatment Vulnerability in Urothelial Carcinoma.
Human mutation - 1 Jan 2026
Tang Chaozhi, Liu Yifan, Wang Tian-Long, Ma Jiakang, Chen Weihua, Liu Xiang, Xue Jingdong, Ye Lin, Yue Feng
Abstract excerpt
At the transcriptomic level, several molecular subtyping schemes have been established to elucidate the intrinsic heterogeneity of urothelial carcinoma and to inform prognostic assessment and therapeutic guidance. However, a unified molecular classification scheme characterizing genomic alterations is lacking. Unsupervised and supervised clustering identified two distinct mutational signature subtypes....
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