Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiregion human bladder cancer sequencing reveals tumour evolution, bladder cancer phenotypes and implications for targeted therapy

5 Feb 2019

Abstract excerpt

We present an evolutionary analysis of the relative time of genetic events underlying tumorigenesis in human bladder cancers from 10 whole cystectomy specimens using multiregional whole-exome sequencing. We timed bladder cancer drivers, mutational signatures, ploidy and copy number alterations, provided evidence for kataegis and correlated alterations with tumour areas and histological phenotypes. We found that:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bladder and Urothelial Cancer Treatments
Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30719704
DOI: 10.1002/path.5250

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiregion human bladder cancer sequencing reveals tumour evolution, bladder cancer phenotypes and implications for targeted therapyPMID 30719704Read ↗

Whole-genome sequencing of bladder cancers reveals somatic CDKN1A mutations and clinicopathological associations with mutation burden.Semantic proximity Read ↗

Single-cell sequencing analysis characterizes common and cell-lineage-specific mutations in a muscle-invasive bladder cancerSemantic proximity Read ↗

Paired Exome Analysis Reveals Clonal Evolution and Potential Therapeutic Targets in Urothelial Carcinoma.Semantic proximity Read ↗

The evolution of bladder cancer genomics: What have we learned and how can we use it?Semantic proximity Read ↗

Comprehensive multiregional analysis of molecular heterogeneity in bladder cancer.Semantic proximity Read ↗

Beyond driver mutations: exploring the landscape of mutational signatures in adenocarcinomas of the bladder†.Semantic proximity Read ↗

Racial differences in genomic features and new trans-ancestry prognosis subtypes in bladder cancerSemantic proximity Read ↗

Molecular Profiling of Bladder Adenocarcinoma Using a National Genomics RepositorySemantic proximity Read ↗

Distinct clonal dynamics and interactions within the microenvironment near tumor stroma interfaces in rare histologic variants of bladder cancerSemantic proximity Read ↗

Somatic mutation profiles of muscle-invasive bladder cancer in Uganda: A cross-sectional study utilising whole-exome sequencingSemantic proximity Read ↗

Distinct mutation profiles between primary bladder cancer and circulating tumor cells warrant the use of circulating tumors cells as cellular resource for mutation follow-upSemantic proximity Read ↗

Evolution of Urothelial Bladder Cancer in the Context of Molecular ClassificationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.