Article
Molecular biology of bladder cancer: new insights into pathogenesis and clinical diversity.
Nature reviews. Cancer - 1 Jan 2015
Knowles Margaret A, Hurst Carolyn D
Abstract excerpt
Urothelial carcinoma of the bladder comprises two long-recognized disease entities with distinct molecular features and clinical outcome. Low-grade non-muscle-invasive tumours recur frequently but rarely progress to muscle invasion, whereas muscle-invasive tumours are usually diagnosed de novo and frequently metastasize. Recent genome-wide expression and sequencing studies identify genes and pathways that are key...
Topics
- Animals
- Biomarkers, Tumor
- Carcinogenesis
- Epigenesis, Genetic
- Gene Expression Regulation, Neoplastic
- Genomic Instability
- Humans
- Mutation
- Signal Transduction
- Urinary Bladder Neoplasms
- Urothelium