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Article

Spatial and temporal clonal evolution during development of metastatic urothelial carcinoma.

Molecular oncology - 1 Nov 2016

Thomsen Mathilde B H, Nordentoft Iver, Lamy Philippe, Høyer Søren, Vang Søren, Hedegaard Jakob, Borre Michael, Jensen Jørgen B, Ørntoft Torben F, Dyrskjøt Lars

Abstract excerpt

Patients with metastatic bladder cancer have a median survival of only 13-14 months. Precision medicine using targeted therapy may improve survival. Here we investigated spatial and temporal tumour evolution and tumour heterogeneity in order to evaluate the potential use of targeted treatment of metastatic bladder cancer. We performed a proof-of-concept study by whole exome sequencing of multiple tumour regions...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27582092
DOI: 10.1016/j.molonc.2016.08.003
PMCID: PMC5423216

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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