Article
Pathological correlations of [F-18]-AV-1451 imaging in non-alzheimer tauopathies.
Annals of neurology - 1 Jan 2017
Marquié Marta, Normandin Marc D, Meltzer Avery C, Siao Tick Chong Michael, Andrea Nicolas V, Antón-Fernández Alejandro, Klunk William E, Mathis Chester A, Ikonomovic Milos D, Debnath Manik, Bien Elizabeth A, Vanderburg Charles R, Costantino Isabel, Makaretz Sara, DeVos Sarah L, Oakley Derek H, Gomperts Stephen N, Growdon John H, Domoto-Reilly Kimiko, Lucente Diane, Dickerson Bradford C, Frosch Matthew P, Hyman Bradley T, Johnson Keith A, Gómez-Isla Teresa
Abstract excerpt
OBJECTIVE: Recent studies have shown that positron emission tomography (PET) tracer AV-1451 exhibits high binding affinity for paired helical filament (PHF)-tau pathology in Alzheimer's brains. However, the ability of this ligand to bind to tau lesions in other tauopathies remains controversial. Our goal was to examine the correlation of in vivo and postmortem AV-1451 binding patterns in three autopsy-confirmed...
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