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Article

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology in MAPT mutation carriers.

Brain : a journal of neurology - 1 Sept 2016

Smith Ruben, Puschmann Andreas, Schöll Michael, Ohlsson Tomas, van Swieten John, Honer Michael, Englund Elisabet, Hansson Oskar

Abstract excerpt

Tau positron emission tomography ligands provide the novel possibility to image tau pathology in vivo However, little is known about how in vivo brain uptake of tau positron emission tomography ligands relates to tau aggregates observed post-mortem. We performed tau positron emission tomography imaging with (18)F-AV-1451 in three patients harbouring a p.R406W mutation in the MAPT gene, encoding tau. This mutation...

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Identifiers

PMID: 27357347
DOI: 10.1093/brain/aww163
PMCID: PMC4995360

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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