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Article

[18F]AV‐1451 PET in behavioral variant frontotemporal dementia due to MAPT mutation

18 Oct 2016

Abstract excerpt

Abstract The validation of tau radioligands could improve the diagnosis of frontotemporal lobar degeneration and the assessment of disease‐modifying therapies. Here, we demonstrate that binding of the tau radioligand [18F]AV‐1451 was significantly abnormal in both magnitude and distribution in a patient with familial frontotemporal dementia due to a MAPT 10 + 16C>T gene mutation, recapitulating the pattern of...

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PMID: 28097206
DOI: 10.1002/acn3.366

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