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Article

[18 F]AV-1451 clustering of entorhinal and cortical uptake in Alzheimer's disease.

Annals of neurology - 1 Feb 2018

Whitwell Jennifer L, Graff-Radford Jonathan, Tosakulwong Nirubol, Weigand Stephen D, Machulda Mary, Senjem Matthew L, Schwarz Christopher G, Spychalla Anthony J, Jones David T, Drubach Daniel A, Knopman David S, Boeve Bradley F, Ertekin-Taner Nilüfer, Petersen Ronald C, Lowe Val J, Jack Clifford R, Josephs Keith A

Abstract excerpt

OBJECTIVE: To use a cluster analysis of [18 F]AV-1451 tau-PET data to determine how subjects with Alzheimer's disease (AD) vary in the relative involvement of the entorhinal cortex and neocortex, and determine whether relative involvement of these two regions can help explain variability in age and clinical phenotype in AD. METHODS: We calculated [18 F]AV-1451 uptake in entorhinal cortex and neocortex in 62...

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Identifiers

PMID: 29323751
DOI: 10.1002/ana.25142
PMCID: PMC5821532

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