Article
In vivo 18F-AV-1451 tau PET signal in MAPT mutation carriers varies by expected tau isoforms.
Neurology - 13 Mar 2018
Jones David T, Knopman David S, Graff-Radford Jonathan, Syrjanen Jeremy A, Senjem Matthew L, Schwarz Christopher G, Dheel Christina, Wszolek Zbigniew, Rademakers Rosa, Kantarci Kejal, Petersen Ronald C, Jack Clifford R, Lowe Val J, Boeve Bradley F
Abstract excerpt
OBJECTIVE: To evaluate 18F-AV-1451 tau PET binding among microtubule-associated protein tau (MAPT) mutation carriers. METHODS: Using a case-control study, we quantitatively and qualitatively compared tau PET scans in 10 symptomatic and 3 asymptomatic MAPT mutation carriers (n = 13, age range 42-67 years) with clinically normal (CN) participants (n = 241, age range 42-67 years) and an Alzheimer disease (AD)...
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