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Article

Frontotemporal dementia with the V337M MAPT mutation: Tau-PET and pathology correlations.

Neurology - 21 Feb 2017

Spina Salvatore, Schonhaut Daniel R, Boeve Bradley F, Seeley William W, Ossenkoppele Rik, O'Neil James P, Lazaris Andreas, Rosen Howard J, Boxer Adam L, Perry David C, Miller Bruce L, Dickson Dennis W, Parisi Joseph E, Jagust William J, Murray Melissa E, Rabinovici Gil D

Abstract excerpt

OBJECTIVE: To assess the efficacy of [18F]AV1451 PET in visualizing tau pathology in vivo in a patient with frontotemporal dementia (FTD) associated with the V337M microtubule-associated protein tau (MAPT) mutation. METHODS: MAPT mutations are associated with the deposition of hyperphosphorylated tau protein in neurons and glia. The PET tracer [18F]AV1451 binds with high affinity to paired helical filaments tau...

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Identifiers

PMID: 28130473
DOI: 10.1212/WNL.0000000000003636
PMCID: PMC5344079

Genes

MAPT

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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