Trio-based GWAS identifies novel associations and subtype-specific risk factors for cleft palate

Abstract excerpt

Cleft palate (CP) is one of the most common craniofacial birth defects; however, there are relatively few established genetic risk factors associated with its occurrence despite high heritability. Historically, CP has been studied as a single phenotype although it manifests across a spectrum of defects involving the hard and/or soft palate. We performed a genome-wide association study (GWAS) using transmission...

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